Basal Ganglia, Nigrostriatal Pathway and Parkinson’s

"Hope arouses, as nothing else can arouse, a passion for the possible." William Sloane Coffin "Walk on, walk on with hope in your heart, and you'll never walk alone, you'll never walk alone." Oscar Hammerstein II Introduction: I have been trying to learn more about brain physiology and the inner workings as it relates to …

Importance of Magnesium in the Brain and Magnesium Threonate is Neuroprotective in a Mouse Model of Parkinson’s

"The world may be broken, but hope is not crazy." John Green "Our eternal message of hope is that dawn will come." Martin Luther King, Jr. Introduction:  Epidemiological studies show that magnesium deficiency is associated with a Parkinson's like syndrome called Parkinson-Dementia Syndrome (PDC). PDC patients have progressive cognitive decline, parkinsonian, and the loss of the …

The 2019 World Parkinson Congress in Kyoto, Japan

"Learning is not attained by chance, it must be sought for with ardor and diligence." Abigail Adams "Believe in yourself and all that you are. Know that there is something inside you that is greater than any obstacle." Christian D. Larson Introduction to the 5th World Parkinson Congress (WPC) in Kyoto, Japan from June 4-7, …

Manganese-induced Parkinsonism Compared to Parkinson’s Disease

"Science is a way of thinking much more than it is a body of knowledge." Carl Sagan "Imagination is more important than knowledge." Albert Einstein What is Manganese? Manganese is abbreviated by the symbol Mn and it is atomic number 25 (see Periodic Table of the Elements).  Manganese is considered a transition metal, which is …

Human Gut Microbes Identified That Process Levodopa

"Symbiosis is a much higher reflection of intelligent life." Frederick Lenz "Why do we do basic research? To learn about ourselves." Walter Gilbert Overview: Reading the article entitled "Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism" from V. Maini Rekdal et al., Science 364, eaau6323 (2019) (DOI: 10.1126/science.aau6323- open access) made …

Neurological Mayhem by Dual Antioxidative and Anti-inflammatory Agents in Aged Parkinson’s Mice

"No person was ever honored for what he received. Honor has been the reward for what he gave." Calvin Coolidge "The most reliable way to predict the future is to create it." Abraham Lincoln Introduction: Recently, Jeff Keegan asked me if I had seen the paper by Gil-Martínez et al., an established Parkinson's research group …

Whey Protein Supplements May Increase Glutathione in Parkinson’s

"Basic research is what I am doing when I don't know what I am doing." Wernher von Braun "As far as the laws of mathematics refer to reality, they are not certain, and as far as they are certain, they do not refer to reality." Albert Einstein Overview: In 1989, Riederer and others demonstrated that …

Brief Report: Link Between Physical Activity and Health-related Quality of Life in Parkinson’s

"The body achieves what the mind believes." Jim Evans “Life is like riding a bicycle. To keep your balance, you must keep moving.” Albert Einstein Overview: Dr. Ehlen and associates work in the Department of Neurology, Charité-University Medicine, Berlin, Germany and Faculty of Psychology and Neuroscience, Maastricht, Netherlands.  Their publication is open-access and is cited …

Journey with Parkinson’s: Brief Reports on Current Research/Issues

"There is a single light of science, and to brighten it anywhere is to brighten it everywhere." Isaac Asimov “Live neither in the past nor in the future, but let each day’s work absorb your entire energies, and satisfy your widest ambition.”  Sir William Osler Introduction: For the following reasons, I would like to introduce and …

Parkinson’s Awareness Month: The Science Behind How Exercise Slows Disease Progression

"Do not let what you cannot do interfere with what you can do." John Wooden "To enjoy the glow of good health, you must exercise." Gene Tunney Précis: For Parkinson's Awareness Month, let's begin with an important reminder/statement that "Exercise is medicine for Parkinson's disease."  Coming soon in a future blog post I will review …