Parkinson’s and Autoimmunity

"I am always doing that which I cannot do, in order that I may learn how to do it." Pablo Picasso "We have more possibilities available in each moment than we realize." Nhat Hanh Précis: This post exists because I received a note from a reader concerned about using a substance that potentially was an …

Word for Wednesday: Parkinsonism

"A correct diagnosis is three-fourths the remedy." Mahatma Gandhi "The art of clinical diagnosis lies in the ability to ask the right questions." Harriet B. Braiker What is Parkinsonism? How is this different from Parkinson's? Parkinson's is a neurodegenerative disorder that destroys dopamine-producing dopaminergic neurons. As Parkinson's progresses, other brain areas are affected, leading to motor- …

10 Lessons Learned About COVID-19 and Parkinson’s

"Come grow old with me. The best is yet to be." William Wordsworth "As long as I am breathing, in my eyes, I am just beginning." Criss Jami Introduction:  Likely, everyone in the world has said the words "COVID-19 Pandemic" at some point since early 2020. From mid-February 2020 to December 2022, more than 324,000 publications …

Happy New Year (2023) from the Journey with Parkinson’s

"Let us resolve to do the best we can with what we've got." William Feather "Maybe this year, we ought to walk through the rooms of our lives not looking for flaws, but looking for potential." Ellen Goodman Happy New Year! In the New Year, may you maintain excellent health, create quality time for loved …

A Graph of Your Daily Level of Exogenous Levodopa

"The greatest achievement is to outperform yourself." Denis Waitley "Sometimes, carrying on, just carrying on, is the superhuman achievement." Albert Camus Introduction: Have you been taking carbidopa/levodopa to treat your Parkinson's? Are you experiencing any off-on periods? Do you have any dyskinesia? Do you think it's time to change your dosing pattern or the timing …

The Complex Role of Neurotransmitters in Parkinson’s

"Resilience is accepting your new reality, even if it's less good than the one you had before." Elizabeth Edwards "Health is wholeness and balance, an inner resilience that allows you to meet the demands of living without being overwhelmed." Andrew Weil Introduction: The goal is to review the role(s) played by dopamine, serotonin, norepinephrine (also …

Six Pillars of Parkinson’s

"In all human affairs there are efforts, and there are results, and the strength of the effort is the measure of the result." James Allen "Storms make trees take deeper roots." Dolly Parton Introduction: In the presence of Parkinson's, each person encounters a different invader that can progress very slowly or evolves quickly. Symptoms expressed are …

Update on Palmitoylethanolamide (PEA) for the Treatment of Parkinson’s

"To the sick, while there is life there is hope. [Lat., Aegroto dum anima est, spes est.]" Marcus Tullius Cicero "We can’t live without hope. When we keep hoping, we keep living." Pete Wilson Introduction: Palmitoylethanolamide (PEA*) is a naturally occurring bioactive lipid that contains a fatty acid moiety and ethanolamide. The molecular formula of …

Rehabilitation Therapy in Parkinson’s

"What you do today can improve all your tomorrows." Ralph Marston "One who gains strength by overcoming obstacles possesses the only strength which can overcome adversity." Albert Schweitzer Introduction: In 2015, I wrote a blog post entitled "Physicians in the Constellation of Care" (click here to read it). The topic was about the importance of …

Effect of Posture and Motility on Drug Availability in the Human Stomach

"The good thing about science is that it's true whether or not you believe in it." Neil deGrasse Tyson "Imagination is more important than knowledge." Albert Einstein Introduction:  Taking something by mouth is a common and relatively easy way to administer a drug. By contrast, when you carefully consider the route, it is a more complex …

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