The Yack on NAC (N-Acetyl-Cysteine) and Parkinson’s

"Once you choose hope, anything's possible." Christopher Reeve "Hope is like a road in the country; there was never a road, but when many people walk on it, the road comes into existence." Lin Yutang Introduction: N-Acetyl-Cysteine (or N-acetylcysteine, usually abbreviated NAC and frequently pronounced like the word 'knack') is an altered (modified by an... Continue Reading →

Help with the Parkinson’s Tremor

"The starting point of all achievement is desire." Napoleon Hill "We can't help everyone, but everyone can help someone." Ronald Reagan The Journey With Parkinson's returns:  The past 2 months have just consumed every waking moment of my time/life, and then some.  I have a back-log of >20 blog posts in some finished-form-or-another. Starting this... Continue Reading →

The 23andMe Parkinson’s Research Study

"Somewhere, something incredible is waiting to be known." Carl Sagan "A dream doesn't become reality through magic; it takes sweat, determination and hard work." Colin Powell Introduction/Background: Parkinson’s disease is a neurodegenerative disorder that affects movement. It evolves slowly, usually starting as either stiffness in a hand or a small tremor. Over time, Parkinson’s progresses;... Continue Reading →

Treatment of Parkinson’s Psychosis with Nuplazid

“At what point do you give up - decide enough is enough? There is only one answer really. Never.” Tabitha Suzuma "Be proud of your scars. They remind you that you have the will to live." Paulo Coelho Précis: ~50% of the people with Parkinson's develop psychotic tendencies. Treatment of their psychosis can be relatively... Continue Reading →

Part 1: Journey to Parkinson’s and Barium Swallow

“It does not do to dwell on dreams and forget to live.” J.K. Rowling, Harry Potter and the Sorcerer's Stone “May you live every day of your life.” Jonathan Swift  Introduction: Along the way to the diagnosis of Parkinson's, you may have to undergo several different kinds of tests to help your physician(s) learn what... Continue Reading →

Importance of Model Systems in Parkinson’s Research

“Science is organized knowledge. Wisdom is organized life.” Will Duran “The most exciting phrase to hear in science, the one that heralds new discoveries, is not 'Eureka!' but 'That's funny...'” Isaac Asimov Introduction:  The goal of this post is to highlight several experimental model systems that have effectively been used in Parkinson's research.  We  have... Continue Reading →

Potential New Parkinson’s Drug Highlight: the Leukemia Drug Nilotinib

“With Parkinson’s you have two choices: You can let it control you, or you can control it. And I’ve chosen to control it.” US Senator Isakson “Learn from yesterday, live for today, hope for tomorrow. The important thing is to not stop questioning.” Albert Einstein Introduction: In my academic career to-date, my research group and I... Continue Reading →

Leucine-rich Repeat Kinase 2 (LRRK2) Is A Possible Target For Therapy In Parkinson’s

“Research is the process of going up alleys to see if they are blind.”  Marston Bates “What we find changes who we become.”  Peter Morville The reality of Parkinson's: Parkinson’s is a common neurodegenerative disorder. Approximately 60,000 new cases/year of Parkinson's occur in the USA, and they join ~1 million people living here with this... Continue Reading →

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