Of Mice And Men: Endogenous Alpha-Synuclein Contributes to Mitochondria Inhibition in Parkinson’s

"There is a single light of science, and to brighten it anywhere is to brighten it everywhere." Isaac Asimov "Do the difficult things while they are easy and do the great things while they are small. A journey of a thousand miles must begin with a single step."  Lao Tzu Science and Parkinson's:  As a …

A Comparison of Parkinson’s to Alzheimer’s

“So many people walk around with a meaningless life. They seem half-asleep, even when they're busy doing things they think are important. This is because they're chasing the wrong things. The way you get meaning into your life is to devote yourself to loving others, devote yourself to your community around you, and devote yourself …

The Alpha-Synuclein Story In Parkinson’s

"The measure of greatness in a scientific idea is the extent to which it stimulates thought and opens up new lines of research.” Paul A.M. Dirac Start of the story: Anyone with Parkinson's is hopeful for a cure in the future. Yet, there is much we still do not understand about this neurodegenerative disorder. Scientists and physicians …

Stumble. Fall. Stand. Adapt. Re-Learn. Keep Going. Stay Strong!

“Every day you may make progress. Every step may be fruitful. Yet there will stretch out before you an ever-lengthening, ever-ascending, ever-improving path. You know you will never get to the end of the journey. But this, so far from discouraging, only adds to the joy and glory of the climb.” Winston Churchill The So-Called …

Where Does Hope Live?

"Hope is important because it can make the present moment less difficult to bear. If we believe that tomorrow will be better, we can bear a hardship today." Thich Nhat Hanh "Hope is being able to see that there is light despite all of the darkness." Desmond Tutu Hope Defined: As a noun, hope is …

A Patient’s Tale

"The good physician treats the disease; the great physician treats the patient who has the disease."  William Osler An Educator: I have had the privilege of being a medical school educator since 1987 (28 years).  The work includes lecturing (to a class of 180 students), small group facilitator (36 students), course management/administration, and curriculum development …

How Do You Feel When You Wake Up Each Morning?

"Today I choose life. Every morning when I wake up I can choose joy, happiness, negativity, pain... To feel the freedom that comes from being able to continue to make mistakes and choices - today I choose to feel life, not to deny my humanity but embrace it."  Kevyn Aucoin "I wake up every morning …

Tremor Tutorial

"No matter how dark the moment, love and hope are always possible."  George Chakiris Start of the Story: Dr. James Parkinson was the first to describe (published in 1817) the condition that now bears his name.  He described Parkinson’s like this: “Involuntary tremulous motion, with lessened muscular power, in parts not in action and even …

Meditation, Yoga, and Exercise in Parkinson’s

“There are moments of frustration in life. You must build good relations to support you in these moments. You must also learn to courage yourself and decide to stay determined in life.”  Lailah Gifty Akita Introduction: Parkinson's is a central nervous system disorder that usually presents with neurodegenerative and movement issues.  In managing Parkinson's, we should work …

Isradipine: Shutting the Door on Calcium Channels to Slow the Progression of Parkinson’s

"The very least you can do in your life is figure out what you hope for. And the most you can do is live inside that hope. Not admire it from a distance but live right in it, under its roof." Barbara Kingsolver Doors Opening and Closing, an Analogy for Calcium Channels:  Carrie Newcomer sings …