Parkinson’s: Two Half-Doses May Work Better Than One Whole Tablet of Levodopa/Carbidopa

"Nature creates unity even in the parts of a whole." Eugene Delacroix "The whole is more than the sum of its parts." Aristotle Hypothesis: A paper published by Chase et al. [Chase, Thomas N., Ahmad AL‐Sabbagh, Minako Koga, and Kathleen Clarence‐Smith. "Reduced Plasma Levodopa Fluctuations with More Frequent Administration of a Novel Carbidopa/Levodopa Functionally Scored …

Update on Complementary and Alternative Medicine (CAM) Therapy in Parkinson’s

"The art of healing comes from nature, not from the physician. Therefore the physician must start from nature, with an open mind." Paracelsus "You know what they call alternative medicine that's been proved to work? - Medicine." Tim Minchin Précis: Regularly, I am asked what I take for treating Parkinson's. This blog post describes the …

Immunomodulating Activity of an Extract from Ashwagandha: Implications for Treatment of Parkinson’s

"The mind, in addition to medicine, has powers to turn the immune system around." Jonas Salk "As you begin to heal the inner you, you alter your immune system." Wayne Dyer Introduction: The current blog post is focused on reviewing an immunomodulating action of an extract from Ashwagandha. Furthermore, I will comment on the use …

Brief Report: Pallidothalamic Tractotomy by Focused Ultrasound for Parkinson’s Disease

"Patience and fortitude conquer all things." Ralph Waldo Emerson "I know of no higher fortitude than stubborness in the face of overwhelming odds." Louis Nizer Overview: Recently, I reviewed a clinical trial involving ablation of the globus pallidus by focused ultrasound to treat Parkinson's (click here to read this blog post). Some time ago, I …

Focused Ultrasound Ablation Therapy of the Globus Pallidus for Parkinson’s

"Be brave. Take risks. Nothing can substitute experience." Paulo Coelho "Resilience is not what happens to you. It’s how you react to, respond to, and recover from what happens to you." Jeffrey Gitomer Introduction: The clinical trial results were published in the New England Journal of Medicine by Krishna et al. (2023), dealing with ultrasound treatment …

Update on Palmitoylethanolamide (PEA) for the Treatment of Parkinson’s

"To the sick, while there is life there is hope. [Lat., Aegroto dum anima est, spes est.]" Marcus Tullius Cicero "We can’t live without hope. When we keep hoping, we keep living." Pete Wilson Introduction: Palmitoylethanolamide (PEA*) is a naturally occurring bioactive lipid that contains a fatty acid moiety and ethanolamide. The molecular formula of …

Exercise and Neuroprotection in Human Parkinson’s: The Long and Winding Road

"It is exercise alone that supports the spirits, and keeps the mind in vigor." Marcus Tullius Cicero "Lack of activity destroys the good condition of every human being." Plato Introduction: I have been convinced for a while that exercise is medicine. This blog post summarizes two publications: Crotty, Grace F., and Michael A. Schwarzschild. "Chasing …

Role of Palmitoylethanolamide to Control Neuroinflammation and Potential Therapy for Parkinson’s

"Our destiny is not determined by the number of times we stumble but by the number of times we rise up, dust ourselves off, and move forward." Dieter F. Uchtdorf "My motto was always to keep swinging. Whether I was in a slump or feeling bad or having trouble off the field, the only thing …

Brief Report: Low-Dose Niacin Improves Motor Function in Parkinson’s

"If you can't explain it simply, you don't understand it well enough." Albert Einstein "Be a voice not an echo." Albert Einstein Abstract: The VA Medical Center in Augusta, Georgia, reported the results of a six-month single-center, double-blind, placebo-controlled randomized study using Parkinson's patients with early- and late-stage disease. They asked the question of whether …

Complementary and Alternative Medicine (CAM) and Over-the-Counter Therapies in Parkinson’s

With Parkinson’s, exercise is better than taking a bottle of pills. If you don’t do anything you’ll just stagnate.” Brian Lambert “With Parkinson’s you have two choices: You can let it control you, or you can control it. And I’ve chosen to control it.” US Senator Isakson Introduction: Having one of the numerous neurodegenerative disorders …