Dopamine Agonists and Impulse Control Disorders in Parkinson’s

"Whenever you are immersed in compulsive thinking, you are avoiding what is. You don't want to be where you are. Here, Now." Eckhart Tolle "Somewhere between obsession and compulsion is impulse." Alexander Pushkin Introduction: In the latest issue of Neurology (June, 2018), Dr. Corvol and collaborators in Paris, France, present the results of a long-term …

Parkinson’s Awareness Month: The Science Behind How Exercise Slows Disease Progression

"Do not let what you cannot do interfere with what you can do." John Wooden "To enjoy the glow of good health, you must exercise." Gene Tunney Précis: For Parkinson's Awareness Month, let's begin with an important reminder/statement that "Exercise is medicine for Parkinson's disease."  Coming soon in a future blog post I will review …

Neuroprotection with Taurine in a Parkinson’s Model System

"There is no medicine like hope, no incentive so great, and no tonic so powerful as expectation of something tomorrow." Orison Swett Marden "Hope sees the invisible, feels the intangible, and achieves the impossible." Helen Keller Introduction: Many of us take levodopa/carbidopa for substantial symptomatic relief; however, this dopamine replacement treatment only relieves symptoms without …

Dopamine Agonist Withdrawal Syndrome (DAWS) in Parkinson’s

"Some remedies are worse than the disease." Publilius Syrus "Each patient carries his own doctor inside him." Norman Cousins Summary: Dopamine agonists are widely used in the treatment of Parkinson's, especially as a first-line therapy. Some patients on a dopamine agonist experience side-effects that require either tapering or discontinuation of the drug.  First described in …

The Yack on NAC (N-Acetyl-Cysteine) and Parkinson’s

"Once you choose hope, anything's possible." Christopher Reeve "Hope is like a road in the country; there was never a road, but when many people walk on it, the road comes into existence." Lin Yutang Introduction: N-Acetyl-Cysteine (or N-acetylcysteine, usually abbreviated NAC and frequently pronounced like the word 'knack') is an altered (modified by an …

“Go the Distance” With MAO-B Inhibitors: Potential Long-term Benefits in Parkinson’s

"Life is 10 percent what you make it, and 90 percent how you take it." Irving Berlin "My attitude is that if you push me towards something that you think is a weakness, then I will turn that perceived weakness into a strength." Michael Jordan Précis:  (1) A brief review of the major classes of …

2016: The Year in Parkinson’s

“The most beautiful experience we can have is the mysterious. It is the fundamental emotion that stands at the cradle of true art and true science.” Albert Einstein “Your assumptions are your windows on the world. Scrub them off every once in a while, or the light won't come in.” Isaac Asimov Summary: (Part 1) …

Part 1: Journey to Parkinson’s and Barium Swallow

“It does not do to dwell on dreams and forget to live.” J.K. Rowling, Harry Potter and the Sorcerer's Stone “May you live every day of your life.” Jonathan Swift  Introduction: Along the way to the diagnosis of Parkinson’s, you may have to undergo several different kinds of examinations. These tests will help your physician(s) …

Importance of Model Systems in Parkinson’s Research

“Science is organized knowledge. Wisdom is organized life.” Will Duran “The most exciting phrase to hear in science, the one that heralds new discoveries, is not 'Eureka!' but 'That's funny...'” Isaac Asimov Introduction:  The goal of this post is to highlight several experimental model systems that have effectively been used in Parkinson's research.  We  have …

Neuroprotection by Modified-Macrophages in a Parkinson’s Model System

“Somewhere, something incredible is waiting to be known.” Carl Sagan “You never change things by fighting the existing reality.  To change something, build a new model that makes the existing model obsolete.” R. Buckminster Fuller Précis: Scientists at the University of North Carolina at Chapel Hill are using an innovative approach to treat Parkinson's in …

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