City Maps: Anticipated Life Span Compared by Zip Codes

“Life is like riding a bicycle. To keep your balance, you must keep moving.” Albert Einstein “Just when you think it can't get any worse, it can. And just when you think it can't get any better, it can.” Nicholas Sparks And Now for Something Completely Different (Monty Python's Flying Circus): City Maps is a …

Anti-malaria Drugs Target Nurr1 For Possible Parkinson’s Therapeutics

“When prescribing one of the drugs I take, my doctor warned me of a common side effect: exaggerated, intensely vivid dreams. To be honest, I've never really noticed the difference. I've always dreamt big.” Michael J. Fox Parkinson's description: About 60,000 new Parkinson's cases will be diagnosed this year in the USA; joining the 1 …

Leucine-rich Repeat Kinase 2 (LRRK2) Is A Possible Target For Therapy In Parkinson’s

“Research is the process of going up alleys to see if they are blind.”  Marston Bates “What we find changes who we become.”  Peter Morville The reality of Parkinson's: Parkinson’s is a common neurodegenerative disorder. Approximately 60,000 new cases/year of Parkinson's occur in the USA, and they join ~1 million people living here with this …

Of Mice And Men: Endogenous Alpha-Synuclein Contributes to Mitochondria Inhibition in Parkinson’s

"There is a single light of science, and to brighten it anywhere is to brighten it everywhere." Isaac Asimov "Do the difficult things while they are easy and do the great things while they are small. A journey of a thousand miles must begin with a single step."  Lao Tzu Science and Parkinson's:  As a …

A Comparison of Parkinson’s to Alzheimer’s

“So many people walk around with a meaningless life. They seem half-asleep, even when they're busy doing things they think are important. This is because they're chasing the wrong things. The way you get meaning into your life is to devote yourself to loving others, devote yourself to your community around you, and devote yourself …

Immune System and Parkinson’s (Part 1): The Brain and Immune System are Connected

“When we least expect it, life sets us a challenge to test our courage and willingness to change; at such a moment, there is no point in pretending that nothing has happened or in saying that we are not yet ready. The challenge will not wait. Life does not look back.” Paulo Coelho What causes …

The Alpha-Synuclein Story In Parkinson’s

"The measure of greatness in a scientific idea is the extent to which it stimulates thought and opens up new lines of research.” Paul A.M. Dirac Start of the story: Anyone with Parkinson's is hopeful for a cure in the future. Yet, there is much we still do not understand about this neurodegenerative disorder. Scientists and physicians …

Isradipine: Shutting the Door on Calcium Channels to Slow the Progression of Parkinson’s

"The very least you can do in your life is figure out what you hope for. And the most you can do is live inside that hope. Not admire it from a distance but live right in it, under its roof." Barbara Kingsolver Doors Opening and Closing, an Analogy for Calcium Channels:  Carrie Newcomer sings …

Dopamine: A Symbol of Hope

"As I ate breakfast one morning, I overheard two oncologists conversing. One complained bitterly, 'You know, Bob, I just don't understand it, We used the same schedule and the same dosage, and the same entry criteria. Yet I got a 22 percent response rate and you got a 74 percent. That's unheard of for metastatic …

PDGF in Parkinson’s Brain May be Like Adding ‘STP’ (Oil Treatment) to Your Automobile

“You may encounter many defeats, but you must not be defeated. In fact, it may be necessary to encounter the defeats, so you can know who you are, what you can rise from, how you can still come out of it.” Maya Angelou Grow factors are substances (proteins) that help regulate cell division and promote …