Neuroprotection by Modified-Macrophages in a Parkinson’s Model System

“Somewhere, something incredible is waiting to be known.” Carl Sagan “You never change things by fighting the existing reality.  To change something, build a new model that makes the existing model obsolete.” R. Buckminster Fuller Précis: Scientists at the University of North Carolina at Chapel Hill are using an innovative approach to treat Parkinson's in …

Potential New Parkinson’s Drug Highlight: the Leukemia Drug Nilotinib

“With Parkinson’s you have two choices: You can let it control you, or you can control it. And I’ve chosen to control it.” US Senator Isakson “Learn from yesterday, live for today, hope for tomorrow. The important thing is to not stop questioning.” Albert Einstein Introduction: In my academic career to-date, my research group and I …

Science of Advanced Age as a Risk Factor for Parkinson’s

“Spring passes and one remembers one's innocence. Summer passes and one remembers one's exuberance. Autumn passes and one remembers one's reverence. Winter passes and one remembers one's perseverance.” Yoko Ono “Embrace aging.” Mitch Albom, Tuesdays with Morrie Précis: The great majority of individuals with Parkinson's reveal no genetic mutations, no past history of head injury, …

Gender Differences as a Factor in Parkinson’s

"Men are from Earth, women are from Earth. Deal with it.” George Carlin “You can either be a victim of the world or an adventurer in search of treasure. It all depends on how you view your life.” Paulo Coelho Précis: ~10% of Parkinson's cases are linked to familial genetic mutations; whereas the vast majority …

Life-Stories and Updates on Parkinson’s Science

“E.E Cummings wrote, "To be nobody-but-yourself in a world which is doing its best, night and day, to make you everybody but yourself - means to fight the hardest battle which any human being can fight- and never stop fighting.” Brené Brown Teaching, and more teaching: I spent most of June and July getting ready …

Parkinson’s and Dementia: Remembering Robin Williams (1951-2014)

“No matter what people tell you, words and ideas can change the world.” Robin Williams Hiding behind the initial diagnosis: When I was diagnosed with Parkinson's 18 months ago, I told my immediate family, a few close friends, and some key people in my research group.  Receiving news that you have a progressive neurodegenerative disorder strikes …

Purple Haze of Parkinson’s: How Dopamine Works

"Life has many ways of testing a person's will, either by having nothing happen at all or by having everything happen all at once.”  Paulo Coelho Précis: To briefly describe the biochemistry of dopamine and dopamine receptors, dopamine physiology, and therapeutic strategies for replacing dopamine in Parkinson's.  But first, some "Purple Haze" by the Jimi …

The Generosity of Donating Your Body to Medical Science

“Don't cry because it's over, smile because it happened.”  Dr. Seuss “May you live every day of your life.”  Jonathan Swift Pros and cons to donating your body to medical science: Likely you've heard about it, maybe you've even thought about it, donating your body to medical science?  It is a generous and altruistic decision …

Anti-malaria Drugs Target Nurr1 For Possible Parkinson’s Therapeutics

“When prescribing one of the drugs I take, my doctor warned me of a common side effect: exaggerated, intensely vivid dreams. To be honest, I've never really noticed the difference. I've always dreamt big.” Michael J. Fox Parkinson's description: About 60,000 new Parkinson's cases will be diagnosed this year in the USA; joining the 1 …

Overview of Neurodegenerative Disorders

"The question is not how to survive, but how to thrive with passion, compassion, humor and style." Maya Angelou "Hardships often prepare ordinary people for an extraordinary destiny." C.S. Lewis   Précis: The goal is to present a brief synopsis of some of the neurodegenerative disorders, that is the easy part.  The hard part is …