“To live is the rarest thing in the world. Most people exist, that is all.” Oscar Wilde “The purpose of life is to live it, to taste experience to the utmost, to reach out eagerly and without fear for newer and richer experience.” Eleanor Roosevelt Life lessons. Life is a series of lessons we gather …
The Song of the Journey Ahead is About Living Authentically in the Presence of Parkinson’s
“Choosing one path means abandoning others – if you try to follow every possible path you will end up following none.” Paulo Coelho "An awareness of one's mortality can lead you to wake up and live an authentic, meaningful life." Bernie Siegel A beginning: ~7 people/hour are diagnosed with Parkinson's in the USA; resulting in …
Purple Haze of Parkinson’s: How Dopamine Works
"Life has many ways of testing a person's will, either by having nothing happen at all or by having everything happen all at once.” Paulo Coelho Précis: To briefly describe the biochemistry of dopamine and dopamine receptors, dopamine physiology, and therapeutic strategies for replacing dopamine in Parkinson's. But first, some "Purple Haze" by the Jimi …
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The Generosity of Donating Your Body to Medical Science
“Don't cry because it's over, smile because it happened.” Dr. Seuss “May you live every day of your life.” Jonathan Swift Pros and cons to donating your body to medical science: Likely you've heard about it, maybe you've even thought about it, donating your body to medical science? It is a generous and altruistic decision …
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Anti-malaria Drugs Target Nurr1 For Possible Parkinson’s Therapeutics
“When prescribing one of the drugs I take, my doctor warned me of a common side effect: exaggerated, intensely vivid dreams. To be honest, I've never really noticed the difference. I've always dreamt big.” Michael J. Fox Parkinson's description: About 60,000 new Parkinson's cases will be diagnosed this year in the USA; joining the 1 …
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Overview of Neurodegenerative Disorders
"The question is not how to survive, but how to thrive with passion, compassion, humor and style." Maya Angelou "Hardships often prepare ordinary people for an extraordinary destiny." C.S. Lewis Précis: The goal is to present a brief synopsis of some of the neurodegenerative disorders, that is the easy part. The hard part is …
Leucine-rich Repeat Kinase 2 (LRRK2) Is A Possible Target For Therapy In Parkinson’s
“Research is the process of going up alleys to see if they are blind.” Marston Bates “What we find changes who we become.” Peter Morville The reality of Parkinson's: Parkinson’s is a common neurodegenerative disorder. Approximately 60,000 new cases/year of Parkinson's occur in the USA, and they join ~1 million people living here with this …
Of Mice And Men: Endogenous Alpha-Synuclein Contributes to Mitochondria Inhibition in Parkinson’s
"There is a single light of science, and to brighten it anywhere is to brighten it everywhere." Isaac Asimov "Do the difficult things while they are easy and do the great things while they are small. A journey of a thousand miles must begin with a single step." Lao Tzu Science and Parkinson's: As a …
A Comparison of Parkinson’s to Alzheimer’s
“So many people walk around with a meaningless life. They seem half-asleep, even when they're busy doing things they think are important. This is because they're chasing the wrong things. The way you get meaning into your life is to devote yourself to loving others, devote yourself to your community around you, and devote yourself …
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Immune System and Parkinson’s (Part 1): The Brain and Immune System are Connected
“When we least expect it, life sets us a challenge to test our courage and willingness to change; at such a moment, there is no point in pretending that nothing has happened or in saying that we are not yet ready. The challenge will not wait. Life does not look back.” Paulo Coelho What causes …
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