Anti-malaria Drugs Target Nurr1 For Possible Parkinson’s Therapeutics

“When prescribing one of the drugs I take, my doctor warned me of a common side effect: exaggerated, intensely vivid dreams. To be honest, I've never really noticed the difference. I've always dreamt big.” Michael J. Fox Parkinson's description: About 60,000 new Parkinson's cases will be diagnosed this year in the USA; joining the 1 …

Overview of Neurodegenerative Disorders

"The question is not how to survive, but how to thrive with passion, compassion, humor and style." Maya Angelou "Hardships often prepare ordinary people for an extraordinary destiny." C.S. Lewis   Précis: The goal is to present a brief synopsis of some of the neurodegenerative disorders, that is the easy part.  The hard part is …

Leucine-rich Repeat Kinase 2 (LRRK2) Is A Possible Target For Therapy In Parkinson’s

“Research is the process of going up alleys to see if they are blind.”  Marston Bates “What we find changes who we become.”  Peter Morville The reality of Parkinson's: Parkinson’s is a common neurodegenerative disorder. Approximately 60,000 new cases/year of Parkinson's occur in the USA, and they join ~1 million people living here with this …

Of Mice And Men: Endogenous Alpha-Synuclein Contributes to Mitochondria Inhibition in Parkinson’s

"There is a single light of science, and to brighten it anywhere is to brighten it everywhere." Isaac Asimov "Do the difficult things while they are easy and do the great things while they are small. A journey of a thousand miles must begin with a single step."  Lao Tzu Science and Parkinson's:  As a …

A Comparison of Parkinson’s to Alzheimer’s

“So many people walk around with a meaningless life. They seem half-asleep, even when they're busy doing things they think are important. This is because they're chasing the wrong things. The way you get meaning into your life is to devote yourself to loving others, devote yourself to your community around you, and devote yourself …

Immune System and Parkinson’s (Part 1): The Brain and Immune System are Connected

“When we least expect it, life sets us a challenge to test our courage and willingness to change; at such a moment, there is no point in pretending that nothing has happened or in saying that we are not yet ready. The challenge will not wait. Life does not look back.” Paulo Coelho What causes …

The Alpha-Synuclein Story In Parkinson’s

"The measure of greatness in a scientific idea is the extent to which it stimulates thought and opens up new lines of research.” Paul A.M. Dirac Start of the story: Anyone with Parkinson's is hopeful for a cure in the future. Yet, there is much we still do not understand about this neurodegenerative disorder. Scientists and physicians …

A Patient’s Tale

"The good physician treats the disease; the great physician treats the patient who has the disease."  William Osler An Educator: I have had the privilege of being a medical school educator since 1987 (28 years).  The work includes lecturing (to a class of 180 students), small group facilitator (36 students), course management/administration, and curriculum development …

Tremor Tutorial

"No matter how dark the moment, love and hope are always possible."  George Chakiris Start of the Story: Dr. James Parkinson was the first to describe (published in 1817) the condition that now bears his name.  He described Parkinson’s like this: “Involuntary tremulous motion, with lessened muscular power, in parts not in action and even …

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