Dopamine Agonists and Impulse Control Disorders in Parkinson’s

"Whenever you are immersed in compulsive thinking, you are avoiding what is. You don't want to be where you are. Here, Now." Eckhart Tolle "Somewhere between obsession and compulsion is impulse." Alexander Pushkin Introduction: In the latest issue of Neurology (June, 2018), Dr. Corvol and collaborators in Paris, France, present the results of a long-term …

Dopamine Agonist Withdrawal Syndrome (DAWS) in Parkinson’s

"Some remedies are worse than the disease." Publilius Syrus "Each patient carries his own doctor inside him." Norman Cousins Summary: Dopamine agonists are widely used in the treatment of Parkinson's, especially as a first-line therapy. Some patients on a dopamine agonist experience side-effects that require either tapering or discontinuation of the drug.  First described in …

B Vitamins (Folate, B6, B12) Reduce Homocysteine Levels Produced by Carbidopa/Levodopa Therapy

"The excitement of vitamins, nutrition and metabolism permeated the environment." Paul D. Boyer "A substance that makes you ill if you don't eat it." Albert Szent-Gyorgy Introduction: Claire McLean, an amazing-PT who is vital to my life managing my Parkinson's, posted a very interesting article about the generation of homocysteine from the metabolism of levodopa …

Milestones in Parkinson’s Disease Research and Discovery

"The real voyage of discovery consists not in seeking new landscapes, but in having new eyes." Marcel Proust "The process of scientific discovery is, in effect, a continual flight from wonder." Albert Einstein Preface:  Happy birthday to James Parkinson (neurologist, geologist, scientist, activist),  born April 11, 1755 and died December 21, 1824.  World Parkinson's Day …

“Go the Distance” With MAO-B Inhibitors: Potential Long-term Benefits in Parkinson’s

"Life is 10 percent what you make it, and 90 percent how you take it." Irving Berlin "My attitude is that if you push me towards something that you think is a weakness, then I will turn that perceived weakness into a strength." Michael Jordan Précis:  (1) A brief review of the major classes of …

200 Years Ago James Parkinson published “An Essay On The Shaking Palsy”

"I have a form of Parkinson's disease, which I don't like. My legs don't move when my brain tells them to. It's very frustrating." George H.W. Bush "I discovered that I was part of a Parkinson's community with similar experiences and similar questions that I'd been dealing with alone." Michael J. Fox Summary: Two hundred …

2016: The Year in Parkinson’s

“The most beautiful experience we can have is the mysterious. It is the fundamental emotion that stands at the cradle of true art and true science.” Albert Einstein “Your assumptions are your windows on the world. Scrub them off every once in a while, or the light won't come in.” Isaac Asimov Summary: (Part 1) …