Parkinson’s: Running on Empty

"I think everyone has the same question on their mind: Is the glass half-full or half-empty?" Oliver Stone "Something has to matter. Otherwise, a person's life will be miserable and empty." Tim Sandlin Introduction: When you think about Parkinson's, it is a disorder where you balance your daily life with enough dopamine or run on …

Reflection on Friday- Dopamine

“Because you are alive, everything is possible.” Thích Nhất Hạnh “Keep swinging.” Hank Aaron Dopamine is Important: Dopamine has the chemical structure of 3,4-dihydroxyphenethylamine and is a member of the catecholamine and phenethylamine families. Dopamine is a neurotransmitter, which means it delivers a message in the central nervous system. The enzyme L-DOPA decarboxylase removes carbon dioxide …

Science Tuesday: Sublingual Carbidopa/Levodopa

"The human brain doesn't come with an instruction manual." Bill Engvall "The great events of the world take place in the brain." Oscar Wilde Levodopa: Levodopa markedly improves motor symptoms for the majority of people with Parkinson’s. The pharmacological effectiveness of levodopa is quite good; however, it has less efficiency in controlling the non-motor symptoms. …

Apathy and Parkinson’s

"Apathy is the acceptance of the unacceptable." John Stott "I don't know, I don't care, and it doesn't make any difference." Jack Kerouac Definition: Apathy (ap·a·thy, /ˈapəTHē/) lack of interest, enthusiasm, or concern. Occurrence of Apathy in Parkinson's: The presence of apathy in Parkinson's is between 17% to 70%, the wide range is partly due …

Basal Ganglia, Nigrostriatal Pathway and Parkinson’s

"Hope arouses, as nothing else can arouse, a passion for the possible." William Sloane Coffin "Walk on, walk on with hope in your heart, and you'll never walk alone, you'll never walk alone." Oscar Hammerstein II Introduction: I have been trying to learn more about brain physiology and the inner workings as it relates to …

The Mask of Parkinson’s

"I wear the mask. It does not wear me." Man in the Iron Mask "See to it, then, that the light within you is not darkness." Luke 11:35 Précis: The simplest way to describe Parkinson's is that it's a movement disorder due to the reduction of dopamine production.  Sometimes one of the more obvious places …

Catching Up, Life-Stories, and Future Posts in Journey With Parkinson’s

"One isn't necessarily born with courage, but one is born with potential. Without courage, we cannot practice any other virtue with consistency. We can't be kind, true, merciful, generous, or honest." Maya Angelou "Life is not a problem to be solved, but an experience to be had." Alan Watts Don't You Get The Summer Off?: …

Science of Advanced Age as a Risk Factor for Parkinson’s

“Spring passes and one remembers one's innocence. Summer passes and one remembers one's exuberance. Autumn passes and one remembers one's reverence. Winter passes and one remembers one's perseverance.” Yoko Ono “Embrace aging.” Mitch Albom, Tuesdays with Morrie Précis: The great majority of individuals with Parkinson's reveal no genetic mutations, no past history of head injury, …

Gender Differences as a Factor in Parkinson’s

"Men are from Earth, women are from Earth. Deal with it.” George Carlin “You can either be a victim of the world or an adventurer in search of treasure. It all depends on how you view your life.” Paulo Coelho Précis: ~10% of Parkinson's cases are linked to familial genetic mutations; whereas the vast majority …

Poetry to Parkinson’s

“The greatest wisdom is in simplicity. Love, respect, tolerance, sharing, gratitude, forgiveness. It's not complex or elaborate. The real knowledge is free. It's encoded in your DNA. All you need is within you. Great teachers have said that from the beginning. Find your heart, and you will find your way.” Carlos Barrios, Mayan elder and …