Basal Ganglia, Nigrostriatal Pathway and Parkinson’s

"Hope arouses, as nothing else can arouse, a passion for the possible." William Sloane Coffin "Walk on, walk on with hope in your heart, and you'll never walk alone, you'll never walk alone." Oscar Hammerstein II Introduction: I have been trying to learn more about brain physiology and the inner workings as it relates to …

The Mask of Parkinson’s

"I wear the mask. It does not wear me." Man in the Iron Mask "See to it, then, that the light within you is not darkness." Luke 11:35 Précis: The simplest way to describe Parkinson's is that it's a movement disorder due to the reduction of dopamine production.  Sometimes one of the more obvious places …

Catching Up, Life-Stories, and Future Posts in Journey With Parkinson’s

"One isn't necessarily born with courage, but one is born with potential. Without courage, we cannot practice any other virtue with consistency. We can't be kind, true, merciful, generous, or honest." Maya Angelou "Life is not a problem to be solved, but an experience to be had." Alan Watts Don't You Get The Summer Off?: …

Science of Advanced Age as a Risk Factor for Parkinson’s

“Spring passes and one remembers one's innocence. Summer passes and one remembers one's exuberance. Autumn passes and one remembers one's reverence. Winter passes and one remembers one's perseverance.” Yoko Ono “Embrace aging.” Mitch Albom, Tuesdays with Morrie Précis: The great majority of individuals with Parkinson's reveal no genetic mutations, no past history of head injury, …

Gender Differences as a Factor in Parkinson’s

"Men are from Earth, women are from Earth. Deal with it.” George Carlin “You can either be a victim of the world or an adventurer in search of treasure. It all depends on how you view your life.” Paulo Coelho Précis: ~10% of Parkinson's cases are linked to familial genetic mutations; whereas the vast majority …

Poetry to Parkinson’s

“The greatest wisdom is in simplicity. Love, respect, tolerance, sharing, gratitude, forgiveness. It's not complex or elaborate. The real knowledge is free. It's encoded in your DNA. All you need is within you. Great teachers have said that from the beginning. Find your heart, and you will find your way.” Carlos Barrios, Mayan elder and …

Purple Haze of Parkinson’s: How Dopamine Works

"Life has many ways of testing a person's will, either by having nothing happen at all or by having everything happen all at once.”  Paulo Coelho Précis: To briefly describe the biochemistry of dopamine and dopamine receptors, dopamine physiology, and therapeutic strategies for replacing dopamine in Parkinson's.  But first, some "Purple Haze" by the Jimi …

Anti-malaria Drugs Target Nurr1 For Possible Parkinson’s Therapeutics

“When prescribing one of the drugs I take, my doctor warned me of a common side effect: exaggerated, intensely vivid dreams. To be honest, I've never really noticed the difference. I've always dreamt big.” Michael J. Fox Parkinson's description: About 60,000 new Parkinson's cases will be diagnosed this year in the USA; joining the 1 …

Of Mice And Men: Endogenous Alpha-Synuclein Contributes to Mitochondria Inhibition in Parkinson’s

"There is a single light of science, and to brighten it anywhere is to brighten it everywhere." Isaac Asimov "Do the difficult things while they are easy and do the great things while they are small. A journey of a thousand miles must begin with a single step."  Lao Tzu Science and Parkinson's:  As a …

A Comparison of Parkinson’s to Alzheimer’s

“So many people walk around with a meaningless life. They seem half-asleep, even when they're busy doing things they think are important. This is because they're chasing the wrong things. The way you get meaning into your life is to devote yourself to loving others, devote yourself to your community around you, and devote yourself …